Approach

OUR APPROACH

The science behind Youngenine

A systems biology approach to healthy aging
Most people lose good health a decade or more before the end of life. In contrast, healthy centenarians stay active, independent, and disease-free into their 90s and beyond. Their biology shows us what’s possible—and where things go wrong in the rest of us.

At YOXLO, we study these biological differences to understand how we can extend healthspan. Our focus lies on cellular energy production, resilience to stress, and immune balance—mechanisms that decline with age and contribute to frailty and disease. These are not abstract concepts; they’re measurable, modifiable, and interconnected.

“Most scientists agree that biologically, humans should be able to live over 100 years in good health.”

Learning from the Exception: Healthy Centenarians
Healthy centenarians are not just lucky. They tend to show better mitochondrial function, lower systemic inflammation, and more stable immune signaling. One notable feature is their low expression of the NLRP3 inflammasome—a key sensor in the innate immune system that is increasingly seen as a master regulator of age-related disease. This concept is explored further in our peer-reviewed review: “The genetic advantage of healthy centenarians: unraveling the central role of NLRP3 in exceptional healthspan” [Read the full article →]

While Youngenine is not a direct NLRP3 inhibitor, it is designed to replicate several of the same downstream effects seen in centenarians: reduced low-grade inflammation, improved metabolic efficiency, and cellular protection.

“Aging and age-related diseases share core mechanisms that largely converge on inflammation.”

Targeting the Biology of Aging
Youngenine is a proprietary blend of bioactive compounds that supports mitochondrial function, reduces oxidative stress, and promotes healthy immune regulation. Together, these actions aim to preserve homeostasis—the body’s capacity to keep internal systems in balance despite aging and external stress.

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Why Mitochondria Matter as We Age
Mitochondria are the tiny power plants inside our cells. They generate the energy needed for everything we do—from thinking and moving to repairing tissues and fighting infections.

But as we age, mitochondria become less efficient. This drop in cellular energy affects muscle strength, brain function, and immune resilience. It’s one of the earliest and most universal changes seen in aging biology.

That’s why supporting mitochondrial health is a key part of our approach. By helping mitochondria work better for longer, we aim to preserve vitality and slow down the physical and mental decline that often comes with aging.

Youngenine is formulated to help support this critical system—keeping your cells energized and your body more resilient.

Why Now Matters
For many chronic diseases, the biological processes start decades before symptoms appear. That means prevention must start earlier too. With Youngenine, our goal is to intervene upstream—supporting the biology of health before decline takes hold.

“For most age-related diseases, treatment comes 10 to 20 years too late.”

A Focus on Healthspan, Not Lifespan
We don’t aim to extend life at all costs. Our mission is to compress the period of decline and extend the years of strength, clarity, and independence. That’s what healthspan means—and that’s what Youngenine is designed to support.

“A healthspan is the part of life free from serious disease and dependency.”

Even the World Health Organization developed a healthy life expectancy indicator (called the HALE) marking the average healthspan by taking the average age of the first occurrence of the most common serious diseases, determining their incidences, and taking the average of those two numbers.

If the average lifespan in the US was 78.79 years in 2019, the HALE for both sexes in the same year is only 66.1 years of age. That leaves the last 12.69 years of the average life faced with the aging and illness we come to associate with growing older.

By supporting YOXLO’s research, you contribute to a future where more people can maintain vitality, strength, and independence as they age—just like healthy centenarians. Join us in advancing science that promotes longer healthspans, not just longer lives.

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Contact
info@yoxlo.com

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YOXLO B.V.
Biopartner 5 Building
De Limes 7
2343 DH Oegstgeest