Healthy aging is a lifelong investment

Yoxlo’s patented research has unlocked the key to prolonging good health as we age

Rethinking old age

Extending Healthspan Through Science

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We’re living longer than ever, but not necessarily better. While medical advancements have extended our lifespan, our healthspan—the years we live in good health—has not kept up. This creates a troubling reality: many people spend the last decade—or more—of their lives living with chronic diseases like heart disease, diabetes, arthritis, and dementia. Instead of adding more vibrant years, we’ve unintentionally extended what’s now being called the diseasespan.

At YOXLO, we’re tackling this challenge head-on. Our mission isn’t just to help people live longer, but to ensure as many of those years as possible are spent in good health. And by closing the healthspan-lifespan gap, we can also reduce the burden of disease later in life.

Supporting YOXLO is an investment in a future where aging is defined by vitality, not decline.

Support our next level of research →

Targeting Healthspan with Youngenine

our vission

Closing the gap between healthspan and lifespan

Biology shows us that humans are capable of living over 100 years in good physical and mental health. Yet, only a rare group of people—healthy centenarians—achieve this ideal. For most of us, the final years of life are marked by chronic illness, highlighting the growing healthspan-lifespan gap.

At YOXLO, we’re working to bridge that gap, so more people can live the majority of their lives in good health—not just the lucky few.

WHY DOES THE HEALTHSPAN-LIFESPAN GAP EXIST?
The gap between healthspan and lifespan is largely driven by chronic inflammation, a hidden, age-related process. This persistent, low-grade inflammation silently damages cells and tissues over time, accelerating the onset of diseases like Alzheimer’s, diabetes, and cardiovascular conditions.

While extending healthspan by adding more healthy years is crucial, reducing the diseasespan—the years spent battling illness—may hold even greater potential. Shrinking this gap is not just a dream; it’s an achievable goal with the right scientific advancements.

A FUTURE WORTH STRIVING FOR
Healthy centenarians inspire us—they live over 100 years in good physical and mental health while staying largely free from age-related diseases. Their exceptional health is not just a matter of luck or lifestyle; it’s deeply rooted in their unique biology. Research strongly suggests they possess a genetic advantage, such as maintaining lower levels of the NLRP3 protein, which is a key driver of chronic inflammation and aging.

At YOXLO, we aim to mimic this genetic advantage. By targeting the biological pathways that enable centenarians to remain healthy, we’re developing innovative solutions to combat the drivers of aging, including chronic inflammation. This approach holds the potential to extend healthspan for everyone—not just the lucky few.

Together, we can bridge the gap between healthspan and lifespan, creating a future where aging is no longer defined by illness but by vitality and independence.

CHRONIC INFLAMMATION: THE SILENT FORCE BEHIND AGING
As we age, low-grade, persistent inflammation quietly takes a toll on the body. This chronic inflammation, driven by key pathways such as NLRP3, accelerates the aging process, damaging cells, tissues, and organs, and paving the way for diseases like arthritis, cancer, and heart disease.

Remarkably, healthy centenarians manage to avoid this damaging cycle, maintaining low levels of NLRP3 and thus sidestepping its harmful effects. By mimicking their biology, as outlined in our review article, we’re uncovering new ways to slow the aging process and improve healthspan.

A NEW FRONTIER IN HEALTHSPAN
At YOXLO, we’re committed to turning cutting-edge science into tangible solutions that help people thrive. Inspired by the resilience of centenarians, our work aims to preserve health, strength, and vitality—empowering you to live not just longer, but better.

Because everyone deserves a future where aging brings new opportunities, not limitations.

Youngenine holds the potential to transform aging by adding more healthy, active years to life, helping people maintain their vitality and independence as they age.

With Youngenine, you’re not just investing in your health—you’re investing in a future where science makes longer, healthier lives possible. Learn more about investing in YOXLO.

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Keep on doing what you love. For longer.

our mission

We pioneer and promote science through curiosity.

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Yoxlo’s name incorporates everything the company strives for, living Younger for Longer, thanks to a groundbreaking X-factor: a health product that helps prolong the human healthspan at a cellular level.

Yoxlo was founded by Dr. Stef Verlinden, a research physician who specializes in gene therapy and cell engineering. Driven to help active people stay younger for longer, Yoxlo is developing a supplement with a compound proven to delay the low-grade inflammation leading to the diseases that often plague us as we grow older.

Stef Verlinden

Founder and Chief Innovation Officer

“Dr. Verlinden imagines a future in which we could delay the inevitable, staying youthful and active for longer than ever before”.

Supporting Yoxlo’s research and development is an investment in both your long-term health and in the science of healthy aging.

After years advancing scientific discovery, including researching gene therapy at Crucell (now Janssen Vaccines), the avid kite surfer, father, and researcher refuses to accept aging in the traditional sense. His life’s work researching rare, hereditary diseases, HIV, and Alzheimer’s lead to discovering how we can all age as well as high-performing centenarians, healthy and free of serious diseases. That is, with a healthy lifestyle and investing in healthy aging now, by preventing the onset of disease instead of treating it once it develops.

Verlinden has filed two patent applications in the United States and European Union for the technology and the method that helps lower a risk factor for disease.

We strive for a fantastic life for all people and will continue to develop novel insights and products to shrink the difference in healthspan between common people and high-performing centenarians.

Challenging the conventional

Yoxlo is a pioneer in the science of healthy aging.

Passion for progress

Our curiosity drives high expectations in research.

Life is extraordinary

Life is too short to be ordinary. Live it to the fullest.

Join us in our mission.

funding

Are you an investor and biotech health pioneer that can bring Yoxlo’s supplement to the next level?

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Yoxlo is actively seeking investors who are equally passionate about the science of better aging and prolonging their own good health. For updates on how you can support the next level of research on Youngenin and be among the first to enjoy its benefits, join our list or email us via the form below.