Blocking NLRP3 extends health and lifespan by almost one-third.
In a groundbreaking study, the research group of Mario D. Cordero found that mice lacking the protein NLRP3 have a 30% increased health and lifespan compared to ordinary and otherwise healthy mice [1].
This study confirms what was found earlier by the group of Visha Dixit, where removing NLRP3 prevented frailty, bone loss, and cognitive decline. As a result, these animals' healthspan - the time lived in good health - is extended. [2]
NLRP3 plays a pivotal role in aging.
The function of NLRP3 is that it is a sensor for the immune system that guards off infections and tissue damage. Luckily it rarely has to come into action.
The problem is that NLRP3 is - promiscuously - activated by compounds we increasingly make in our bodies as we age. For example, amyloid-β aggregates and cholesterol crystals. A poor lifestyle accelerates this process.
The result is an almost unnoticeable chronic low-grade inflammation. As we know now, this plays a pivotal role in the pathology of nearly all age-related diseases. In mice, blocking NLRP3 prevents these diseases and extends their health- and lifespan.
At Yoxlo we are convinced the same can be done in humans, making it possible to add more healthy years to one's life.
References
- Marín-Aguilar F, Lechuga-Vieco AV, et al. NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice. Aging Cell. 2020 Jan;19(1):e13050.
- Youm YH, Grant RW, et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab. 2013 Oct 1;18(4):519-32.
